Nobel-winning therapy weaponises immune system against cancer

James Allison of the US and Tasuku Honjo of Japan won the Nobel on Monday for identifying two different brakes on the immune system which, when turned off, allow the body's defence system to attack cancerous cells faster and more effectively. Allison was one of two scientists to discover the blocking effect for one such brake -- or checkpoint inhibitor molecule -- called CTLA-4 in 1995.

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